Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists

HIV infection results in a decrease in circulating CD4(+) T-cell and naive T-cell numbers. If such losses were associated with an erosion of T-cell receptor (TCR) repertoire diversity in the peripheral T-cell pool, this might exacerbate the state of persistent immunodeficiency. Existing methods for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Baum, Paul D., Young, Jennifer J., Schmidt, Diane, Zhang, Qianjun, Hoh, Rebecca, Busch, Michael, Martin, Jeffrey, Deeks, Steven, McCune, Joseph M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2012
Pynciau:
Immunobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325037/
https://ncbi.nlm.nih.gov/pubmed/22371879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-395384
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