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The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition

API-1 is a novel small molecule inhibitor of Akt, which acts by binding to Akt and preventing its membrane translocation, and has promising preclinical antitumor activity. In this study, we reveal a novel function of API-1 in regulation of c-FLIP levels and tumor necrosis factor-related apoptosis-in...

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Autors principals: Li, Bo, Ren, Hui, Yue, Ping, Chen, Mingwei, Khuri, Fadlo R., Sun, Shi-Yong
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324640/
https://ncbi.nlm.nih.gov/pubmed/22345097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0548
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