Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

BACKGROUND: Geranylgeranyltransferase I (GGTase I) has emerged as a cancer therapeutic target. Accordingly, small molecules that inhibit GGTase I have been developed and exhibit encouraging anticancer activity in preclinical studies. However, their underlying anticancer mechanisms remain unclear. He...

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Detalhes bibliográficos
Main Authors: Chen, Shuzhen, Fu, Lei, Raja, Shruti M, Yue, Ping, Khuri, Fadlo R, Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824632/
https://ncbi.nlm.nih.gov/pubmed/20113484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-23
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