TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion

In cancer progression, carcinoma cells gain invasive behavior through a loss of epithelial characteristics and acquisition of mesenchymal properties, a process that can lead to epithelial–mesenchymal transition (EMT). TGF-β is a potent inducer of EMT, and increased TGF-β signaling in cancer cells is...

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Bibliografiske detaljer
Main Authors: Lamouille, Samy, Connolly, Erin, Smyth, James W., Akhurst, Rosemary J., Derynck, Rik
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2012
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324583/
https://ncbi.nlm.nih.gov/pubmed/22399812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.095299
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