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Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s Disease
Rat septal cells, induced to enter a terminal differentiation-like state by temperature shift, produce prion protein (PrP) levels 7x higher than their proliferative counterparts. Host PrP accumulates on the plasma membrane, newly elaborated nanotubes, and cell-to-cell junctions, important conduits f...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3324552/ https://ncbi.nlm.nih.gov/pubmed/22509412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035471 |
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