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Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s Disease

Rat septal cells, induced to enter a terminal differentiation-like state by temperature shift, produce prion protein (PrP) levels 7x higher than their proliferative counterparts. Host PrP accumulates on the plasma membrane, newly elaborated nanotubes, and cell-to-cell junctions, important conduits f...

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Autors principals: Miyazawa, Kohtaro, Kipkorir, Terry, Tittman, Sarah, Manuelidis, Laura
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324552/
https://ncbi.nlm.nih.gov/pubmed/22509412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035471
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