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Prevention of Wear Particle-Induced Osteolysis by a Novel V-ATPase Inhibitor Saliphenylhalamide through Inhibition of Osteoclast Bone Resorption

Wear particle-induced peri-implant loosening (Aseptic prosthetic loosening) is one of the most common causes of total joint arthroplasty. It is well established that extensive bone destruction (osteolysis) by osteoclasts is responsible for wear particle-induced peri-implant loosening. Thus, inhibiti...

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Main Authors: Qin, An, Cheng, Tak S., Lin, Zhen, Cao, Lei, Chim, Shek M., Pavlos, Nathan J., Xu, Jiake, Zheng, Ming Hao, Dai, Ke Rong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324493/
https://ncbi.nlm.nih.gov/pubmed/22509274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034132
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