The GPI Anchor Signal Sequence Dictates the Folding and Functionality of the Als5 Adhesin from Candida albicans

BACKGROUND: Proteins destined to be Glycosylphosphatidylinositol (GPI) anchored are translocated into the ER lumen completely before the C-terminal GPI anchor attachment signal sequence (SS) is removed by the GPI-transamidase and replaced by a pre-formed GPI anchor precursor. Does the SS have a role...

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Main Authors: Ahmad, Mohammad Faiz, Yadav, Bhawna, Kumar, Pravin, Puri, Amrita, Mazumder, Mohit, Ali, Anwar, Gourinath, Samudrala, Muthuswami, Rohini, Komath, Sneha Sudha
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324464/
https://ncbi.nlm.nih.gov/pubmed/22509405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035305
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