Surfactant Protein D Deficiency in Mice Is Associated with Hyperphagia, Altered Fat Deposition, Insulin Resistance, and Increased Basal Endotoxemia

Pulmonary surfactant protein D (SP-D) is a host defence lectin of the innate immune system that enhances clearance of pathogens and modulates inflammatory responses. Recently it has been found that systemic SP-D is associated with metabolic disturbances and that SP-D deficient mice are mildly obese....

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Bibliographic Details
Main Authors: Stidsen, Jacob V., Khorooshi, Reza, Rahbek, Martin K. U., Kirketerp-Møller, Katrine L., Hansen, Pernille B. L., Bie, Peter, Kejling, Karin, Mandrup, Susanne, Hawgood, Samuel, Nielsen, Ole, Nielsen, Claus H., Owens, Trevor, Holmskov, Uffe, Sørensen, Grith L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324408/
https://ncbi.nlm.nih.gov/pubmed/22509382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035066
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