Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA

Neuroblastoma is a common childhood malignant tumor originated from the neural crest-derived sympathetic nervous system. A crucial early event in neuroblastoma pathogenesis is arrested differentiation of neuroblasts at various stages. Treatment of neuroblastoma with TPA and PDGF-BB leads to terminal...

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Bibliographic Details
Main Authors: Mei, Yang, Wang, Zhanxiang, Zhang, Lei, Zhang, Yiru, Li, Xiaoyu, Liu, Huihui, Ye, Jing, You, Han
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323967/
https://ncbi.nlm.nih.gov/pubmed/22411791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119535109
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