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Correcting human mitochondrial mutations with targeted RNA import
Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects, and aging. An efficient and simple mechanism for neutralizing deleterious mitochondrial DNA (mtDNA) alterations has unfortunately remained elusive. Here, we report that a 20-ribonucleotide stem-l...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3323963/ https://ncbi.nlm.nih.gov/pubmed/22411789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116792109 |
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