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Correcting human mitochondrial mutations with targeted RNA import

Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects, and aging. An efficient and simple mechanism for neutralizing deleterious mitochondrial DNA (mtDNA) alterations has unfortunately remained elusive. Here, we report that a 20-ribonucleotide stem-l...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Geng, Shimada, Eriko, Zhang, Jin, Hong, Jason S., Smith, Geoffrey M., Teitell, Michael A., Koehler, Carla M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323963/
https://ncbi.nlm.nih.gov/pubmed/22411789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116792109
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