Nucleotides released from Aβ(1–42)-treated microglial cells increase cell migration and Aβ(1–42) uptake through P2Y(2) receptor activation

Amyloid β-protein (Aβ) deposits in brains of Alzheimer’s disease (AD) patients generate proinflammatory cytokines and chemokines that recruit microglial cells to phagocytose Aβ. Nucleotides released from apoptotic cells activate P2Y(2) receptors (P2Y(2)Rs) in macrophages to promote clearance of dead...

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Main Authors: Kim, Hye Jung, Ajit, Deepa, Peterson, Troy S., Wang, Yanfang, Camden, Jean M., Wood, W. Gibson, Sun, Grace Y., Erb, Laurie, Petris, Michael, Weisman, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323761/
https://ncbi.nlm.nih.gov/pubmed/22353164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07700.x
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