IL-1β ENHANCES NUCLEOTIDE-INDUCED AND α-SECRETASE-DEPENDENT APP PROCESSING IN RAT PRIMARY CORTICAL NEURONS VIA UPREGULATION OF THE P2Y(2) RECEPTOR

The heterologous expression and activation of the human P2Y(2) nucleotide receptor (P2Y(2)R) in human 1321N1 astrocytoma cells stimulates α-secretase-dependent cleavage of the amyloid precursor protein (APP), causing extracellular release of the non-amyloidogenic protein sAPPα. To determine whether...

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Main Authors: Kong, Qiongman, Peterson, Troy S., Baker, Olga, Stanley, Emily, Camden, Jean, Seye, Cheikh I., Erb, Laurie, Simonyi, Agnes, Wood, W. Gibson, Sun, Grace Y., Weisman, Gary A.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710802/
https://ncbi.nlm.nih.gov/pubmed/19317852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06048.x
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