Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation

BACKGROUND: New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-in...

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Hauptverfasser: Lin, Eliane Q., Irvine, Jennifer C., Cao, Anh H., Alexander, Amy E., Love, Jane E., Patel, Ruchi, McMullen, Julie R., Kaye, David M., Kemp-Harper, Barbara K., Ritchie, Rebecca H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323591/
https://ncbi.nlm.nih.gov/pubmed/22506056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034892
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