Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

BACKGROUND: Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In the present study, we investigated the possible preventive effects of 4-O-methyl...

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Detalhes bibliográficos
Main Authors: Lee, Young-Jung, Choi, Dong-Young, Choi, Im Seop, Kim, Ki Ho, Kim, Young Hee, Kim, Hwan Mook, Lee, Kiho, Cho, Won Gil, Jung, Jea Kyung, Han, Sang Bae, Han, Jin-Yi, Nam, Sang-Yoon, Yun, Young Won, Jeong, Jae Hwang, Oh, Ki-Wan, Hong, Jin Tae
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323460/
https://ncbi.nlm.nih.gov/pubmed/22339795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-35
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