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Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Age...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3323137/ https://ncbi.nlm.nih.gov/pubmed/22249165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.260 |
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