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Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Age...

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書誌詳細
主要な著者: Kaushik, Susmita, Arias, Esperanza, Kwon, Hyokjoon, Lopez, Nuria Martinez, Athonvarangkul, Diana, Sahu, Srabani, Schwartz, Gary J, Pessin, Jeffrey E, Singh, Rajat
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323137/
https://ncbi.nlm.nih.gov/pubmed/22249165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.260
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