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The binding site for the liver-specific transcription factor Tf-LF1 and the TATA box of the human transferrin gene promoter are the only elements necessary to direct liver-specific transcription in vitro.

We have studied the liver-specific transcriptional activity of the human transferrin gene promoter. Results of competition experiments, site-directed mutagenesis, and 5' deletion analysis have demonstrated that a TATA box and a binding site for the liver-specific protein Tf-LF1 are the only ele...

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Autori principali: Mendelzon, D, Boissier, F, Zakin, M M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC332305/
https://ncbi.nlm.nih.gov/pubmed/2216764
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