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Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

Neuropilin-1 (Nrp1) is an essential receptor for angiogenesis that binds to VEGF-A. Nrp1 binds directly to VEGF-A with high affinity, but the nature of their selective binding has remained unclear. Nrp1 was initially reported to bind to the exon 7-encoded region of VEGF-A and function as an isoform-...

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Detaylı Bibliyografya
Asıl Yazarlar: Parker, Matthew W., Xu, Ping, Li, Xiaobo, Vander Kooi, Craig W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322888/
https://ncbi.nlm.nih.gov/pubmed/22318724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331140
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