Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress

Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial activation, and they increase the adhesion of the endothelium to circulating leukocytes. Nevertheless, the mechanisms underlying these effects remain unclear. We observed that in HNE-treated human umbilical vein...

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Main Authors: Vladykovskaya, Elena, Sithu, Srinivas D., Haberzettl, Petra, Wickramasinghe, Nalinie S., Merchant, Michael L., Hill, Bradford G., McCracken, James, Agarwal, Abhinav, Dougherty, Susan, Gordon, Sharon A., Schuschke, Dale A., Barski, Oleg A., O'Toole, Timothy, D'Souza, Stanley E., Bhatnagar, Aruni, Srivastava, Sanjay
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322871/
https://ncbi.nlm.nih.gov/pubmed/22228760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320416
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