5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-d-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization

N-Methyl-d-aspartate (NMDA)-gated ion channels are known to play a critical role in motoneuron depolarization, but the molecular mechanisms modulating NMDA activation in the spinal cord are not well understood. This study demonstrates that activated 5HT2C receptors enhance NMDA depolarizations recor...

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Detalhes bibliográficos
Main Authors: Bigford, Gregory E., Chaudhry, Nauman S., Keane, Robert W., Holohean, Alice M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322813/
https://ncbi.nlm.nih.gov/pubmed/22291020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277806
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