Combination of Chemical Genetics and Phosphoproteomics for Kinase Signaling Analysis Enables Confident Identification of Cellular Downstream Targets

Delineation of phosphorylation-based signaling networks requires reliable data about the underlying cellular kinase-substrate interactions. We report a chemical genetics and quantitative phosphoproteomics approach that encompasses cellular kinase activation in combination with comparative replicate...

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Detalhes bibliográficos
Main Authors: Oppermann, Felix S., Grundner-Culemann, Kathrin, Kumar, Chanchal, Gruss, Oliver J., Jallepalli, Prasad V., Daub, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Technological Innovation and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322579/
https://ncbi.nlm.nih.gov/pubmed/22199227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.O111.012351
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