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How Conformational Dynamics of DNA Polymerase Select Correct Substrates: Experiments and Simulations

Nearly every enzyme undergoes a significant change in structure after binding it’s substrate. New experimental and theoretical analyses of the role of changes in HIV reverse transcriptase structure in selecting a correct substrate are presented. Atomically detailed simulations using the Milestoning...

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Autors principals: Kirmizialtin, Serdal, Nguyen, Virginia, Johnson, Kenneth A., Elber, Ron
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322391/
https://ncbi.nlm.nih.gov/pubmed/22483109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.02.018
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