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How Conformational Dynamics of DNA Polymerase Select Correct Substrates: Experiments and Simulations
Nearly every enzyme undergoes a significant change in structure after binding it’s substrate. New experimental and theoretical analyses of the role of changes in HIV reverse transcriptase structure in selecting a correct substrate are presented. Atomically detailed simulations using the Milestoning...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322391/ https://ncbi.nlm.nih.gov/pubmed/22483109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.02.018 |
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