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Phosphorylated MAPK/ERK1/2 may not always represent its kinase activity in a rat model of focal cerebral ischemia with or without ischemic preconditioning

The ERK 1/2 protein require a dual phosphorylation at conserved threonine and tyrosine residues to be fully activated under normal physiological conditions. Thus, ERK1/2 kinase activity is often defined by the quantity of phosphorylated kinase. However, this may not accurately represent its true act...

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Detalhes bibliográficos
Main Authors: Takahashi, Tetsuya, Steinberg, Gary K., Zhao, Heng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322316/
https://ncbi.nlm.nih.gov/pubmed/22366512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.02.005
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