Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells

BACKGROUND: Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating proinflammatory gene expression. By favouring GR monomer formation, CpdA does not enhance glucocorticoid (GC) response element-driven ge...

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Detalhes bibliográficos
Main Authors: Liberman, Ana C., Antunica-Noguerol, Maria, Ferraz-de-Paula, Viviane, Palermo-Neto, Joao, Castro, Carla N., Druker, Jimena, Holsboer, Florian, Perone, Marcelo J., Gerlo, Sarah, De Bosscher, Karolien, Haegeman, Guy, Arzt, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322149/
https://ncbi.nlm.nih.gov/pubmed/22496903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035155
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