Leukotriene C4 induces migration of human monocyte–derived dendritic cells without loss of immunostimulatory function

Generation of human monocyte–derived dendritic cells (DCs) for cancer vaccination involves ex vivo maturation in the presence of proinflammatory cytokines and prostaglandin E(2) (PGE(2)). Although the inclusion of PGE(2) during maturation is imperative for the induction of DC migration, PGE(2) has u...

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Autors principals: Dannull, Jens, Schneider, Tristan, Lee, Walter T., de Rosa, Nicole, Tyler, Douglas S., Pruitt, Scott K.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321871/
https://ncbi.nlm.nih.gov/pubmed/22323449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-385930
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