The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Synthetic triterpenoids are multitarget compounds exhibiting promise as preventative and therapeutic agents for cancer. Their proposed mechanism of action is by forming Michael adducts with reactive nucleophilic groups on target proteins. Our previous work demonstrates that the 2-cyano-3,12-dioxoole...

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Détails bibliographiques
Auteurs principaux: Bernstein, Steven H., Venkatesh, Sundararajan, Li, Min, Lee, Jae, Lu, Bin, Hilchey, Shannon P., Morse, Kimberly M., Metcalfe, Hollie M., Skalska, Jolanta, Andreeff, Michael, Brookes, Paul S., Suzuki, Carolyn K.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321858/
https://ncbi.nlm.nih.gov/pubmed/22323447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-340075
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