The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

Synthetic triterpenoids are multitarget compounds exhibiting promise as preventative and therapeutic agents for cancer. Their proposed mechanism of action is by forming Michael adducts with reactive nucleophilic groups on target proteins. Our previous work demonstrates that the 2-cyano-3,12-dioxoole...

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Detalhes bibliográficos
Main Authors: Bernstein, Steven H., Venkatesh, Sundararajan, Li, Min, Lee, Jae, Lu, Bin, Hilchey, Shannon P., Morse, Kimberly M., Metcalfe, Hollie M., Skalska, Jolanta, Andreeff, Michael, Brookes, Paul S., Suzuki, Carolyn K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321858/
https://ncbi.nlm.nih.gov/pubmed/22323447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-340075
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