The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes Intrinsically Resistant Ovarian Cancer Cells to Cisplatin by Lowering the Threshold Set by Bcl-x(L) and Mcl-1

Ovarian cancer is the number one cause of death from gynecologic malignancy. A defective p53 pathway is a hallmark of ovarian carcinoma. The p53 mutation correlates significantly with resistance to platinum-based chemotherapy, early relapse and shortened overall survival in ovarian cancer patients....

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Autors principals: Yuan, Zhu, Cao, Kang, Lin, Chao, Li, Lei, Liu, Huan-yi, Zhao, Xin-yu, Liu, Lei, Deng, Hong-xin, Li, Jiong, Nie, Chun-lai, Wei, Yu-quan
Format: Artigo
Idioma:Inglês
Publicat: ScholarOne 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321807/
https://ncbi.nlm.nih.gov/pubmed/21863213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00176
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