Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

Noninvasive intranasal drug administration has been noted to allow direct delivery of drugs to the brain. In the present study, the therapeutic efficacy of intranasal small interfering RNA (siRNA) delivery was investigated in the postischemic rat brain. Fluorescein isothiocyanate (FITC)-labeled cont...

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Detalhes bibliográficos
Main Authors: Kim, Il-Doo, Shin, Joo-Hyun, Kim, Seung-Woo, Choi, Sunghyun, Ahn, Junseong, Han, Pyung-Lim, Park, Jong-Sang, Lee, Ja-Kyeong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321593/
https://ncbi.nlm.nih.gov/pubmed/22252450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.291
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