Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

In the gut of patients with Crohn's disease (CD), high Smad7 blocks the immune-suppressive activity of transforming growth factor (TGF)-β1, thereby contributing to amplify inflammatory signals. In vivo in mice, knockdown of Smad7 with a Smad7 antisense oligonucleotide (GED0301) attenuates exper...

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Detalhes bibliográficos
Main Authors: Monteleone, Giovanni, Fantini, Massimo C, Onali, Sara, Zorzi, Francesca, Sancesario, Giulia, Bernardini, Sergio, Calabrese, Emma, Viti, Francesca, Monteleone, Ivan, Biancone, Livia, Pallone, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321586/
https://ncbi.nlm.nih.gov/pubmed/22252452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.290
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