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Continuous δ-Opioid Receptor Activation Reduces Neuronal Voltage-Gated Sodium Channel (Na(V)1.7) Levels through Activation of Protein Kinase C in Painful Diabetic Neuropathy
The Na(V)1.7 tetrodotoxin-sensitive voltage-gated sodium channel isoform plays a critical role in nociception. In rodent models of diabetic neuropathy, increased Na(V)1.7 in dorsal root ganglia (DRG) neurons correlates with the emergence of pain-related behaviors characteristic of painful diabetic n...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321315/ https://ncbi.nlm.nih.gov/pubmed/18579738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5530-07.2008 |
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