A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

The G protein-coupled receptor (GPCR) Proteolysis Site (GPS) of cell-adhesion GPCRs and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism remains unknown. Here, we show that unexpectedly the ∼40-residue GPS motif represents...

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Huvudupphovsmän: Araç, Demet, Boucard, Antony A, Bolliger, Marc F, Nguyen, Jenna, Soltis, S Michael, Südhof, Thomas C, Brunger, Axel T
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321182/
https://ncbi.nlm.nih.gov/pubmed/22333914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.26
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