Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor

The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, yet its structure and mechanism of chromatin recruitment remain unknown. In yeast, this complex has been described as a heterotetramer (Tho2, Hpr1, Mft1, and Thp2) that interact...

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Main Authors: Peña, Álvaro, Gewartowski, Kamil, Mroczek, Seweryn, Cuéllar, Jorge, Szykowska, Aleksandra, Prokop, Andrzej, Czarnocki-Cieciura, Mariusz, Piwowarski, Jan, Tous, Cristina, Aguilera, Andrés, Carrascosa, José L, Valpuesta, José María, Dziembowski, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321177/
https://ncbi.nlm.nih.gov/pubmed/22314234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.10
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