Cargando...
Access to “Friedel-Crafts-restricted” tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols
Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate 3° benzylic alcohols are activated with SOCl(2) or concentrated HCl, and then treated with trimethylaluminum, affording the desired products in 68–97% yields (22 examples). This reaction sequence is successful in...
Gardado en:
| Main Authors: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321128/ https://ncbi.nlm.nih.gov/pubmed/22394317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo202371c |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|