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Access to “Friedel-Crafts-restricted” tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols
Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate 3° benzylic alcohols are activated with SOCl(2) or concentrated HCl, and then treated with trimethylaluminum, affording the desired products in 68–97% yields (22 examples). This reaction sequence is successful in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321128/ https://ncbi.nlm.nih.gov/pubmed/22394317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo202371c |
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