Single-Chain VαVβ T Cell Receptors Function Without Mispairing With Endogenous TCR Chains

Transduction of exogenous T cell receptor (TCR) genes into patients’ activated peripheral blood T cells is a potent strategy to generate large numbers of specific T cells for adoptive therapy of cancer and viral diseases. However, the remarkable clinical promise of this powerful approach is still be...

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Detalhes bibliográficos
Main Authors: Aggen, David H., Chervin, Adam S., Schmitt, Thomas M., Engels, Boris, Stone, Jennifer D., Richman, Sarah A., Piepenbrink, Kurt H., Baker, Brian M., Greenberg, Philip D., Schreiber, Hans, Kranz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321103/
https://ncbi.nlm.nih.gov/pubmed/21753797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.104
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