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Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats

Mammalian target of rapamycin (mTOR) controls mRNA translation and is critical for neuronal plasticity. However, how it participates in central sensitization underlying chronic pain is unclear. Here, we show that NMDA receptors are required for the functional role of spinal cord mTOR in bone cancer...

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Bibliografiske detaljer
Main Authors: Shih, Ming-Hung, Kao, Sheng-Chin, Wang, Wei, Yaster, Myron, Tao, Yuan-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321092/
https://ncbi.nlm.nih.gov/pubmed/22341316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2011.12.006
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