Development of clickable active site-directed photoaffinity probes for γ-secretase

We have developed clickable active site-directed photoaffinity probes for γ-secretase which incorporate a photoreactive benzophenone group and an alkyne handle for subsequent click chemistry mediated conjugation with azide-linked reporter tags for visualization (e.g., TAMRA-azide) or enrichment (e.g...

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Bibliografiske detaljer
Main Authors: Crump, Christina J., am Ende, Christopher W., Ballard, T. Eric, Pozdnyakov, Nikolay, Pettersson, Martin, Chau, De-Ming, Bales, Kelly R., Li, Yue-Ming, Johnson, Douglas S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321063/
https://ncbi.nlm.nih.gov/pubmed/22418280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.02.027
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