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Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps f...

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Библиографические подробности
Главные авторы: Machado, Diana, Couto, Isabel, Perdigão, João, Rodrigues, Liliana, Portugal, Isabel, Baptista, Pedro, Veigas, Bruno, Amaral, Leonard, Viveiros, Miguel
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321020/
https://ncbi.nlm.nih.gov/pubmed/22493700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034538
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