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Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps f...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Machado, Diana, Couto, Isabel, Perdigão, João, Rodrigues, Liliana, Portugal, Isabel, Baptista, Pedro, Veigas, Bruno, Amaral, Leonard, Viveiros, Miguel
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321020/
https://ncbi.nlm.nih.gov/pubmed/22493700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034538
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