First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

γ-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-β (Aβ) peptides. The Aβ42 peptide in particular plays a pivotal role in Alzheimer disease pathogenesis and represents a major drug target. Several γ-secretase modulators (G...

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Detalhes bibliográficos
Main Authors: Borgegard, Tomas, Juréus, Anders, Olsson, Fredrik, Rosqvist, Susanne, Sabirsh, Alan, Rotticci, Didier, Paulsen, Kim, Klintenberg, Rebecka, Yan, Hongmei, Waldman, Magnus, Stromberg, Kia, Nord, Johan, Johansson, Jonas, Regner, Anna, Parpal, Santiago, Malinowsky, David, Radesater, Ann-Cathrin, Li, Tingsheng, Singh, Rajeshwar, Eriksson, Hakan, Lundkvist, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320929/
https://ncbi.nlm.nih.gov/pubmed/22334705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.305227
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