p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy

p38 MAPK has been strongly implicated in the development of atherosclerosis, but its role in cholesterol ester accumulation in macrophages and formation of foam cells, an early step in the development of atherosclerosis, has not been investigated. We addressed this issue and made some brand new obse...

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Bibliografiske detaljer
Main Authors: Mei, Shuang, Gu, Haihua, Ward, Adam, Yang, Xuefeng, Guo, Huailan, He, Ka, Liu, Zhenqi, Cao, Wenhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320924/
https://ncbi.nlm.nih.gov/pubmed/22354961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333575
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