Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis

Psoriasis is characterized by hyperplasia of the epidermis and infiltration of leukocytes into both the dermis and epidermis. IL-23, a key cytokine that induces T(H)17 cells, has been found to play a critical role in the pathogenesis of psoriasis. Apilimod is a small-molecule compound that selective...

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Detalhes bibliográficos
Main Authors: Wada, Yumiko, Cardinale, Irma, Khatcherian, Artemis, Chu, John, Kantor, Aaron B., Gottlieb, Alice B., Tatsuta, Noriaki, Jacobson, Eric, Barsoum, James, Krueger, James G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320873/
https://ncbi.nlm.nih.gov/pubmed/22493730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035069
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