Analysis of Polymorphisms and Haplotype Structure of the Human Thymidylate Synthase Genetic Region: A Tool for Pharmacogenetic Studies

5-fluorouracil (5FU), a widely used chemotherapeutic drug, inhibits the DNA replicative enzyme, thymidylate synthase (Tyms). Prior studies implicated a VNTR (variable numbers of tandem repeats) polymorphism in the 5′-untranslated region (5′-UTR) of the TYMS gene as a determinant of Tyms expression i...

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Main Authors: Ghosh, Soma, Hossain, M. Zulfiquer, Borges, Michael, Goggins, Michael G., Ingersoll, Roxann G., Eshleman, James R., Klein, Alison P., Kern, Scott E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320636/
https://ncbi.nlm.nih.gov/pubmed/22496803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034426
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