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Reexamining a proposal: Thymidylate synthase 5′-untranslated region as a regulator of translation efficiency

The DNA replicative gene, thymidylate synthase (TYMS), is inhibited upon treatment with the anticancer drug 5-fluorouracil (5-FU). TYMS has 28-bp tandem repeat sequences or VNTR (variable numbers of tandem repeats) in the 5′-untranslated region (5′-UTR). The number of these repeats is variable in an...

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Bibliografische gegevens
Hoofdauteurs: Ghosh, Soma, Winter, Jordan M, Patel, Kalpesh, Kern, Scott E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218528/
https://ncbi.nlm.nih.gov/pubmed/21811101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.8.16867
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