Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores

Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities. One conformer forms cation-selective pores that permeabilize phagocyte membrane for efflux of cytosolic potassium. The other con...

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Detalhes bibliográficos
Main Authors: Fiser, Radovan, Masin, Jiri, Bumba, Ladislav, Pospisilova, Eva, Fayolle, Catherine, Basler, Marek, Sadilkova, Lenka, Adkins, Irena, Kamanova, Jana, Cerny, Jan, Konopasek, Ivo, Osicka, Radim, Leclerc, Claude, Sebo, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320606/
https://ncbi.nlm.nih.gov/pubmed/22496638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002580
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