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CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

LPS-activated neutrophils secrete IL-1β by activation of TLR-4. Based on studies in macrophages, it is likely that ROS and lysosomal destabilization regulated by Syk activation may also be involved. Since neutrophils have abundant expression of the ITIM-containing co-receptor CEACAM1 and Gram-negati...

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Detalhes bibliográficos
Main Authors: Lu, Rongze, Pan, Hao, Shively, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320586/
https://ncbi.nlm.nih.gov/pubmed/22496641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002597
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