Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of IDH1 and IDH2 have recently been reported in some types of brain tumors and a small pro...

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Detalhes bibliográficos
Main Authors: Chotirat, Sadudee, Thongnoppakhun, Wanna, Promsuwicha, Orathai, Boonthimat, Chetsada, Auewarakul, Chirayu U
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320529/
https://ncbi.nlm.nih.gov/pubmed/22397365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-5
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