A new strategy to decrease N-methyl-d-aspartate (NMDA) receptor coactivation: Inhibition of d-serine synthesis by converting serine racemase into an eliminase

Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d-aspartate (NMDA) receptors. We now report that serine racemase catalyzes an elimination reaction toward a nonphysiological substrate that provides a powerful tool to study...

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Autors principals: Panizzutti, Rogério, De Miranda, Joari, Ribeiro, Cátia S., Engelender, Simone, Wolosker, Herman
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC33203/
https://ncbi.nlm.nih.gov/pubmed/11309496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091002298
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