A new strategy to decrease N-methyl-d-aspartate (NMDA) receptor coactivation: Inhibition of d-serine synthesis by converting serine racemase into an eliminase

Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d-aspartate (NMDA) receptors. We now report that serine racemase catalyzes an elimination reaction toward a nonphysiological substrate that provides a powerful tool to study...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Panizzutti, Rogério, De Miranda, Joari, Ribeiro, Cátia S., Engelender, Simone, Wolosker, Herman
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33203/
https://ncbi.nlm.nih.gov/pubmed/11309496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091002298
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares