A new strategy to decrease N-methyl-d-aspartate (NMDA) receptor coactivation: Inhibition of d-serine synthesis by converting serine racemase into an eliminase

Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d-aspartate (NMDA) receptors. We now report that serine racemase catalyzes an elimination reaction toward a nonphysiological substrate that provides a powerful tool to study...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Panizzutti, Rogério, De Miranda, Joari, Ribeiro, Cátia S., Engelender, Simone, Wolosker, Herman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091002298
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